Tocagen Reports Results of Toca 5 Phase 3 Trial in Recurrent Brain Cancer
Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)
Unfortunately the trial did not meet it's endpoint of median overall survival. I did not really expect it to as the immunotherapies appear to help only a small subset of patients, but when they do - it helps a lot. This leads to a long tail of survivors, but the median does not change. All of the immunotherapies by themselves will probably have this same problem. I think the key is to combine them to the point where most people benefit. I wouldn't write this off until we see the complete results and see if there is a signficant tail.
Posted on: 09/13/2019
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